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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 39% Improvement Relative Risk Ventilation 6% ICU admission 52% Death/hospitalization 25% Recovery time 17% c19budesonide.com Yu et al. Budesonide for COVID-19 RCT LATE TREATMENT Favors budesonide Favors control
Yu, 1,856 patient budesonide late treatment RCT: 39% lower mortality [p=0.45], 6% lower ventilation [p=1], 52% lower ICU admission [p=0.07], and 25% lower combined mortality/hospitalization [p=0.96] https://c19p.org/yu3
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Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial
Yu et al., The Lancet, doi:10.1016/S0140-6736(21)01744-X (date from earlier preprint)
12 Apr 2021    Source   PDF   Share   Tweet
Interim results from the PRINCIPLE trial, 1,073 treated with budesonide starting a median of 6 days after symptom onset, showing lower hospitalization/death, and faster recovery with treatment. ISRCTN86534580.
risk of death, 39.1% lower, RR 0.61, p = 0.45, treatment 6 of 787 (0.8%), control 10 of 799 (1.3%), NNT 204.
risk of mechanical ventilation, 6.0% lower, RR 0.94, p = 1.00, treatment 13 of 776 (1.7%), control 14 of 784 (1.8%), NNT 905.
risk of ICU admission, 52.0% lower, RR 0.48, p = 0.07, treatment 10 of 771 (1.3%), control 21 of 779 (2.7%), NNT 71.
risk of death/hospitalization, 25.0% lower, RR 0.75, p = 0.96, treatment 72 of 787 (9.1%), control 116 of 1,069 (10.9%), NNT 59, adjusted per study, day 28.
recovery time, 17.4% lower, relative time 0.83, p = 0.001, treatment 787, control 1,069, adjusted per study, inverted to make RR<1 favor treatment.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yu et al., 12 Apr 2021, Randomized Controlled Trial, United Kingdom, peer-reviewed, 24 authors, average treatment delay 6.0 days.
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