|In Vitro||et al., bioRxiv, doi:10.1101/2021.05.05.442779 (Preprint) (In Vitro)||in vitro||ProLung™-budesonide Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation|
|Details In Vitro study and animal study showing that ProLung™-budesonide inhibits SARS-CoV-2 replication (results for budesonide were not provided). ProLung™-budesonide and budesonide significantly decreased lung inflammation. ProLung™-budesonide..|
|Late||et al., medRxiv, doi:10.1101/2021.04.10.21254672 (Preprint)||hosp./death, ↓17.5%, p=0.24||Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial|
|Details Interim results from the PRINCIPLE trial, 751 treated with budesonide starting a median of 6 days after symptom onset, showing lower hospitalization/death, and faster recovery with treatment.|
|Early||et al., Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00160-0 (preprint 2/8) (Peer Reviewed)||hosp./ER, ↓81.8%, p=0.02||Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial|
|Details RCT with 73 budesonide patients and 73 control patients, showing significantly lower combined risk of an ER visit or hospitalization, and lower risk of no recovery at day 14.|
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