8/23 Prophylaxis study
et al., The Journal of Allergy and Clinical Immunology: In Practice, doi:10.1016/j.jaip.2021.08.007 (Peer Reviewed)
Intranasal Corticosteroids Are Associated with Better Outcomes in Coronavirus Disease 2019
Intranasal Corticosteroids Are Associated with Better Outcomes in Coronavirus Disease 2019
Retrospective 72,147 COVID-19+ patients in the USA, showing lower mortality, ICU admission, and hospitalization with intranasal corticosteroid use.
risk of death, 23.5% lower, RR 0.76, p = 0.01, treatment 231 of 10,187 (2.3%), control 1,649 of 61,960 (2.7%), adjusted per study, odds ratio converted to relative risk, PSM.
risk of ICU admission, 22.3% lower, RR 0.78, p = 0.003, treatment 376 of 10,187 (3.7%), control 2,559 of 61,960 (4.1%), adjusted per study, odds ratio converted to relative risk, PSM.
risk of hospitalization, 18.9% lower, RR 0.81, p < 0.001, treatment 1,676 of 10,187 (16.5%), control 10,932 of 61,960 (17.6%), adjusted per study, odds ratio converted to relative risk, PSM.
Strauss et al., 8/23/2021, retrospective, USA, North America, peer-reviewed, 8 authors, 1 April, 2020 - 31 March, 2021.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical significance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All
practical, effective, and safe means should be used. Elimination of COVID-19
is a race against viral evolution. No treatment, vaccine, or intervention is
100% available and effective for all current and future variants. Denying the
efficacy of any method increases the risk of COVID-19 becoming endemic; and
increases mortality, morbidity, and collateral damage. We do not provide
medical advice. Before taking any medication, consult a qualified physician
who can provide personalized advice and details of risks and benefits based
on your medical history and situation. Treatment protocols for physicians are
available from the FLCCC.