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Budesonide study #1 of 4   All Outcomes
2/8 Early treatment study
Ramakrishnan et al., Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00160-0 (preprint 2/8) (Peer Reviewed)
Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial
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RCT with 73 budesonide patients and 73 control patients, showing significantly lower combined risk of an ER visit or hospitalization, and lower risk of no recovery at day 14.

Ramakrishnan et al., 2/8/2021, Randomized Controlled Trial, United Kingdom, Europe, peer-reviewed, 24 authors.
risk of hospitalization/ER, 81.8% lower, RR 0.18, p = 0.02, treatment 2 of 73 (2.7%), control 11 of 73 (15.1%), ITT.
risk of hospitalization/ER, 90.1% lower, RR 0.10, p = 0.004, treatment 1 of 70 (1.4%), control 10 of 69 (14.5%), PP.
risk of no recovery, 67.1% lower, RR 0.33, p = 0.003, treatment 7 of 70 (10.0%), control 21 of 69 (30.4%), PP, day 14.
recovery time, 12.5% lower, relative time 0.88, treatment 70, control 69, PP.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 4 studies   All Outcomes
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