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Home   COVID-19 treatment studies for Budesonide  COVID-19 treatment studies for Budesonide  C19 studies: Budesonide  Budesonide   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization/ER 82% Improvement Relative Risk Hospitalization/ER (b) 90% Recovery 67% Recovery time 12% no CI c19budesonide.com Ramakrishnan et al. Budesonide for COVID-19 RCT EARLY Favors budesonide Favors control
Ramakrishnan, 146 patient budesonide early treatment RCT: 82% fewer combined hospitalization/ER visits [p=0.02] and 67% improved recovery [p=0.003] https://c19p.org/ramakrishnan
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Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial
Ramakrishnan et al., Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00160-0 (preprint 2/8)
8 Feb 2021    Source   PDF   Share   Tweet
RCT with 73 budesonide patients and 73 control patients, showing significantly lower combined risk of an ER visit or hospitalization, and lower risk of no recovery at day 14.
risk of hospitalization/ER, 81.8% lower, RR 0.18, p = 0.02, treatment 2 of 73 (2.7%), control 11 of 73 (15.1%), NNT 8.1, ITT.
risk of hospitalization/ER, 90.1% lower, RR 0.10, p = 0.004, treatment 1 of 70 (1.4%), control 10 of 69 (14.5%), NNT 7.7, PP.
risk of no recovery, 67.1% lower, RR 0.33, p = 0.003, treatment 7 of 70 (10.0%), control 21 of 69 (30.4%), NNT 4.9, PP, day 14.
recovery time, 12.5% lower, relative time 0.88, treatment 70, control 69, PP.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ramakrishnan et al., 2/8/2021, Randomized Controlled Trial, United Kingdom, Europe, peer-reviewed, 24 authors, average treatment delay 3.0 days.
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