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0 0.5 1 1.5 2+ Mortality 74% Improvement Relative Risk Ventilation 76% Hospitalization time 20% c19budesonide.com Gavriilidis et al. NCT05279391 Budesonide LATE Favors budesonide Favors control
Gavriilidis, 48 patient budesonide late treatment study: 74% lower mortality [p=0.05], 76% lower ventilation [p=0.02], and 20% shorter hospitalization [p=0.02] https://c19p.org/gavriilidis
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Combined administration of inhaled DNase, baricitinib and tocilizumab as rescue treatment in COVID-19 patients with severe respiratory failure
Gavriilidis et al., Clinical Immunology, doi:10.1016/j.clim.2022.109016, NCT05279391 (history)
18 Apr 2022    Source   PDF   Share   Tweet
Small retrospective study of hospitalized patients with severe respiratory failure, 22 treated with a combination of budesonide, tocilizumab, baricitinib, dornase alfa, and salbutamol or/and ipratropium, and 26 SOC patients, showing lower mortality and intubation with treatment. The average age of the combined treatment group was 6 years younger than the SOC group.
risk of death, 73.7% lower, RR 0.26, p = 0.045, treatment 2 of 22 (9.1%), control 9 of 26 (34.6%), NNT 3.9.
risk of mechanical ventilation, 76.4% lower, RR 0.24, p = 0.02, treatment 2 of 22 (9.1%), control 10 of 26 (38.5%), NNT 3.4.
hospitalization time, 19.6% lower, relative time 0.80, p = 0.02, treatment mean 15.6 (±5.3) n=22, control mean 19.4 (±7.2) n=26.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
Gavriilidis et al., 18 Apr 2022, retrospective, Greece, peer-reviewed, 19 authors, study period 25 October, 2020 - 18 August, 2021, this trial uses multiple treatments in the treatment arm (combined with tocilizumab, baricitinib, dornase alfa, and salbutamol or/and ipratropium) - results of individual treatments may vary, trial NCT05279391 (history).
Contact: pskendro@med.duth.gr, kritis@med.duth.gr.
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