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0 0.5 1 1.5 2+ Mortality, day 28 80% Improvement Relative Risk Mortality, day 14 67% Hospitalization, day 28 -36% Hospitalization, day 14 -30% Progression, day 28 -20% Progression, day 14 -13% primary c19budesonide.com Duvignaud et al. NCT04356495 Budesonide RCT EARLY Favors budesonide Favors Vitamins A, ..
Duvignaud, 217 patient budesonide early treatment RCT: 80% lower mortality [p=0.24], 36% higher hospitalization [p=0.52], and 20% higher progression [p=0.69] https://c19p.org/duvignaud
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Inhaled ciclesonide for outpatient treatment of COVID-19 in adults at risk of adverse outcomes: a randomised controlled trial (COVERAGE)
Duvignaud et al., Clinical Microbiology and Infection, doi:10.1016/j.cmi.2022.02.031, NCT04356495 (history)
16 Mar 2022    Source   PDF   Share   Tweet
Early terminated RCT with 110 ciclesonide patients and 107 patients treated with vitamins A, B1, B2, B3, B5, B6, B8, B9, B12, C, D3, and E, calcium, chromium, copper, iron, manganese, molybdenum, selenium, and zinc (Azinc Vitality), showing no significant differences between the two treatments. There was no control group. NCT04356495 (history). EudraCT 2020-001435-27.
risk of death, 80.2% lower, RR 0.20, p = 0.24, treatment 0 of 110 (0.0%), control 2 of 107 (1.9%), NNT 54, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 28.
risk of death, 67.0% lower, RR 0.33, p = 0.49, treatment 0 of 110 (0.0%), control 1 of 107 (0.9%), NNT 107, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14.
risk of hospitalization, 36.2% higher, RR 1.36, p = 0.52, treatment 14 of 110 (12.7%), control 10 of 107 (9.3%), day 28.
risk of hospitalization, 29.7% higher, RR 1.30, p = 0.65, treatment 12 of 110 (10.9%), control 9 of 107 (8.4%), day 14.
risk of progression, 19.7% higher, RR 1.20, p = 0.69, treatment 16 of 110 (14.5%), control 13 of 107 (12.1%), oxygen, hospitalization, or death, day 28.
risk of progression, 13.5% higher, RR 1.13, p = 0.84, treatment 14 of 110 (12.7%), control 12 of 107 (11.2%), oxygen, hospitalization, or death, day 14, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in meta analysis: trials compares against another treatment showing significant efficacy in trials.
Duvignaud et al., 16 Mar 2022, Randomized Controlled Trial, France, peer-reviewed, median age 63.0, 314 authors, average treatment delay 4.0 days, this trial compares with another treatment - results may be better when compared to placebo, trial NCT04356495 (history).
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