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Budesonide study #8   All Outcomes
10/27 Early treatment study
Baker et al., medRxiv, doi:10.1101/2021.10.26.21265512 (Preprint)
Dampening of the respiratory cytokine storm is promoted by inhaled budesonide in patients with early COVID-19
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Analysis of inflammatory mediators in the nasal mucosa of patients in the STOIC1 trial and a cohort of SARS-CoV-2 negative controls, showing that budesonide treatment decreased IL-33 and IFN-γ, implying a reduction in epithelial damage and dampening of the interferon response. Treatment also increased CCL17 concentrations, suggesting improved T-cell response.
Baker et al., 10/27/2021, preprint, 10 authors.
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