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Home   COVID-19 treatment studies for Budesonide  COVID-19 treatment studies for Budesonide  C19 studies: Budesonide  Budesonide   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality -23% Improvement Relative Risk Progression 39% c19budesonide.com Agustí et al. NCT04355637 Budesonide RCT LATE TREATMENT Favors budesonide Favors control
Agustí, 89 patient budesonide late treatment RCT: 23% higher mortality [p=1] and 39% lower progression [p=0.69] https://c19p.org/agusti2
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Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trial
Agustí et al., European Respiratory Journal, doi:10.1183/13993003.03036-2021
10 Feb 2022    Source   PDF   Share   Tweet
Small early-terminated RCT with 40 inhaled budesonide and 49 control patients, showing no significant differences. 400µg/12h via Pulmicort Turbuhaler. TACTIC. NCT04355637.
risk of death, 22.5% higher, RR 1.23, p = 1.00, treatment 1 of 40 (2.5%), control 1 of 49 (2.0%), day 90.
risk of progression, 38.7% lower, RR 0.61, p = 0.69, treatment 2 of 40 (5.0%), control 4 of 49 (8.2%), NNT 32.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Agustí et al., 2/10/2022, Randomized Controlled Trial, Spain, Europe, peer-reviewed, 21 authors, trial NCT04355637.
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This PaperBudesonideAll
Late treatment
is less effective
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